Insulin degludec early clinical experience: does the promise from the clinical trials translate into clinical practice—a case-based evaluation

Evaluation of Clinical Trials

In a number of important clinical issues such as evaluation of the efficacy or effectiveness of therapeutic or preventive interventions as well as for comparing the harms of interventions, randomized controlled trials (RCTs) provide the highest levels of evidence, either directly or indirectly. It is obvious that critical appraisal of these studies to assess their validity and precision is of p...

Evidence Based Medicine: Clinical Trials

Evidence based medicine is very important for success of modern medicine. It is the ongoing process of using the most reliable evidence from clinical studies, scientific understanding and medical practice to make the best possible medical choice for patients. Evidence based medicine is how medicine advances and how we get improvements in life expectancy and quality of life. It not only identifi...

Aripiprazole: does partial dopaminergic agonism translate into clinical benefits?

EDITORIALS A lthough the exact biological mechanisms involved in schizophrenia remain unknown, it is widely accepted that monoamine neurotransmitters (e.g., dopamine) play a key role in the symptomatology and pathophysiology of the disease. Since the discovery that the efficacy of pheno-thiazines was associated with blocking dopaminergic receptors , dopaminergic circuitry of the brain has been ...

pharmacogenetics, the promise of translating personalized medicine into clinical pediatrics

Why we can't translate clinical trials into clinical practice in hypertension.

We live in an era, like many in the recent past, where new approaches to the diagnosis and treatment of medical conditions have greatly altered our daily activities as physicians. However, the increasingly used epidemiologic approach to medicine, based on the assessment of the average behavior of large populations, is often used as a substitute for the information previously available to the ph...